Assay Detail
Functional
CHEMBL3095122
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Cytotoxicity against human H1299 cells assessed as growth inhibition after 48 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1299 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Oxime-based inhibitors of glucose transporter 1 displaying antiproliferative effects in cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.56 | 4.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL449451 | — | — | 1 | 4.85 |
| CHEMBL480612 | — | — | 1 | 4.69 |
| CHEMBL3092944 | — | — | 1 | 4.69 |
| CHEMBL479638 | — | — | 1 | 4.46 |
| CHEMBL479837 | — | — | 1 | 4.40 |
| CHEMBL45068 | PHLORETIN | — | 1 | 4.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL449451 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL480612 | — | IC50 | = | 20400.0 | nM | 4.69 |
| CHEMBL3092944 | — | IC50 | = | 20400.0 | nM | 4.69 |
| CHEMBL479638 | — | IC50 | = | 34800.0 | nM | 4.46 |
| CHEMBL479837 | — | IC50 | = | 39600.0 | nM | 4.40 |
| CHEMBL45068 | PHLORETIN | IC50 | = | 54000.0 | nM | 4.27 |