Assay Detail
Binding
CHEMBL3095124
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GLUT1 in human H1299 cells assessed as inhibition of 2-deoxy-D-[3H]-glucose uptake incubated for 15 mins prior to 2-deoxy-D-[3H]-glucose addition measured after 30 mins by liquid scintillation counting analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | H1299 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Solute carrier family 2, facilitated glucose transporter member 1 (CHEMBL2535) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Oxime-based inhibitors of glucose transporter 1 displaying antiproliferative effects in cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.85 | 5.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL449451 | — | — | 1 | 5.07 |
| CHEMBL479638 | — | — | 1 | 4.97 |
| CHEMBL3092944 | — | — | 1 | 4.96 |
| CHEMBL479837 | — | — | 1 | 4.81 |
| CHEMBL45068 | PHLORETIN | — | 1 | 4.67 |
| CHEMBL480612 | — | — | 1 | 4.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL449451 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL479638 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL3092944 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL479837 | — | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL45068 | PHLORETIN | IC50 | = | 21400.0 | nM | 4.67 |
| CHEMBL480612 | — | IC50 | = | 23400.0 | nM | 4.63 |