Assay Detail
Binding
CHEMBL3095184
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human endothelial lipase using HDL as substrate assessed as release of free fatty acids preincubated for 30 mins followed by substrate addition measured after 2 hrs
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of XEN445: a potent and selective endothelial lipase inhibitor raises plasma HDL-cholesterol concentration in mice.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.81 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3093392 | — | — | 1 | 6.96 |
| CHEMBL3093394 | — | — | 1 | 6.92 |
| CHEMBL3093393 | — | — | 1 | 6.89 |
| CHEMBL3093395 | — | — | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3093392 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3093394 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3093393 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3093395 | — | IC50 | = | 330.0 | nM | 6.48 |