Assay Detail
Binding
CHEMBL3095191
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Inhibition of recombinant human hepatic lipase using bis-BODIPY-FL C11-PC as substrate preincubated for 30 mins followed by substrate addition by FELA method
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of XEN445: a potent and selective endothelial lipase inhibitor raises plasma HDL-cholesterol concentration in mice.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 4.76 | 5.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3093405 | — | — | 1 | 5.19 |
| CHEMBL3093302 | — | — | 1 | 5.12 |
| CHEMBL3093392 | — | — | 1 | 5.02 |
| CHEMBL3093393 | — | — | 1 | 4.77 |
| CHEMBL3093394 | — | — | 1 | 4.71 |
| CHEMBL3093395 | — | — | 1 | 4.63 |
| CHEMBL3093391 | — | — | 1 | 4.62 |
| CHEMBL3093399 | — | — | 1 | 4.05 |
| CHEMBL3093400 | — | — | 1 | - |
| CHEMBL3093300 | — | — | 1 | - |
| CHEMBL3093301 | — | — | 1 | - |
| CHEMBL3093398 | — | — | 1 | - |
| CHEMBL3093303 | — | — | 1 | - |
| CHEMBL3093304 | — | — | 1 | - |
| CHEMBL3093305 | — | — | 1 | - |
| CHEMBL3093306 | — | — | 1 | - |
| CHEMBL3093307 | — | — | 1 | - |
| CHEMBL3093308 | — | — | 1 | - |
| CHEMBL3093309 | — | — | 1 | - |
| CHEMBL3093397 | — | — | 1 | - |
| CHEMBL3093396 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3093405 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL3093302 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL3093392 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL3093393 | — | IC50 | = | 16920.0 | nM | 4.77 |
| CHEMBL3093394 | — | IC50 | = | 19500.0 | nM | 4.71 |
| CHEMBL3093395 | — | IC50 | = | 23300.0 | nM | 4.63 |
| CHEMBL3093391 | — | IC50 | = | 24110.0 | nM | 4.62 |
| CHEMBL3093399 | — | IC50 | = | 88310.0 | nM | 4.05 |
| CHEMBL3093400 | — | IC50 | - | — | - | |
| CHEMBL3093300 | — | IC50 | - | — | - | |
| CHEMBL3093301 | — | IC50 | - | — | - | |
| CHEMBL3093398 | — | IC50 | - | — | - | |
| CHEMBL3093303 | — | IC50 | - | — | - | |
| CHEMBL3093304 | — | IC50 | - | — | - | |
| CHEMBL3093305 | — | IC50 | - | — | - | |
| CHEMBL3093306 | — | IC50 | - | — | - | |
| CHEMBL3093307 | — | IC50 | - | — | - | |
| CHEMBL3093308 | — | IC50 | - | — | - | |
| CHEMBL3093309 | — | IC50 | - | — | - | |
| CHEMBL3093397 | — | IC50 | - | — | - | |
| CHEMBL3093396 | — | IC50 | - | — | - |