Assay Detail
Binding
CHEMBL3095194
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Inhibition of recombinant human endothelial lipase using bis-BODIPY-FL C11-PC as substrate preincubated for 30 mins followed by substrate addition by FELA method
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of XEN445: a potent and selective endothelial lipase inhibitor raises plasma HDL-cholesterol concentration in mice.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.52 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3093304 | — | — | 1 | 7.60 |
| CHEMBL3093396 | — | — | 1 | 7.06 |
| CHEMBL3093307 | — | — | 1 | 6.88 |
| CHEMBL3093309 | — | — | 1 | 6.81 |
| CHEMBL3093302 | — | — | 1 | 6.74 |
| CHEMBL3093401 | — | — | 1 | 6.68 |
| CHEMBL3093395 | — | — | 1 | 6.67 |
| CHEMBL3093393 | — | — | 1 | 6.66 |
| CHEMBL3093308 | — | — | 1 | 6.63 |
| CHEMBL3093306 | — | — | 1 | 6.63 |
| CHEMBL3093392 | — | — | 1 | 6.62 |
| CHEMBL3093394 | — | — | 1 | 6.60 |
| CHEMBL3093303 | — | — | 1 | 6.59 |
| CHEMBL3093391 | — | — | 1 | 6.44 |
| CHEMBL3093305 | — | — | 1 | 6.43 |
| CHEMBL3093398 | — | — | 1 | 6.30 |
| CHEMBL3093399 | — | — | 1 | 6.26 |
| CHEMBL3093397 | — | — | 1 | 6.24 |
| CHEMBL3093400 | — | — | 1 | 6.18 |
| CHEMBL3093405 | — | — | 1 | 6.00 |
| CHEMBL3093301 | — | — | 1 | 5.71 |
| CHEMBL3093404 | — | — | 1 | 5.71 |
| CHEMBL3093402 | — | — | 1 | - |
| CHEMBL3093403 | — | — | 1 | - |
| CHEMBL3093300 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3093304 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3093396 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL3093307 | — | IC50 | = | 131.0 | nM | 6.88 |
| CHEMBL3093309 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL3093302 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL3093401 | — | IC50 | = | 209.0 | nM | 6.68 |
| CHEMBL3093395 | — | IC50 | = | 214.0 | nM | 6.67 |
| CHEMBL3093393 | — | IC50 | = | 219.0 | nM | 6.66 |
| CHEMBL3093308 | — | IC50 | = | 236.0 | nM | 6.63 |
| CHEMBL3093306 | — | IC50 | = | 236.0 | nM | 6.63 |
| CHEMBL3093392 | — | IC50 | = | 237.0 | nM | 6.62 |
| CHEMBL3093394 | — | IC50 | = | 252.0 | nM | 6.60 |
| CHEMBL3093303 | — | IC50 | = | 259.0 | nM | 6.59 |
| CHEMBL3093391 | — | IC50 | = | 366.0 | nM | 6.44 |
| CHEMBL3093305 | — | IC50 | = | 372.0 | nM | 6.43 |
| CHEMBL3093398 | — | IC50 | = | 499.0 | nM | 6.30 |
| CHEMBL3093399 | — | IC50 | = | 551.0 | nM | 6.26 |
| CHEMBL3093397 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL3093400 | — | IC50 | = | 659.0 | nM | 6.18 |
| CHEMBL3093405 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL3093301 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL3093404 | — | IC50 | = | 1946.0 | nM | 5.71 |
| CHEMBL3093402 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3093403 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3093300 | — | IC50 | > | 10000.0 | nM | - |