Assay Detail
Functional
CHEMBL3095334
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against drug-resistant HIV1 RES056 harboring reverse transcriptase K103N/Y181C double mutant infected in human MT-4 cells assessed as protection against virus-induced cytopathicity after 5 days by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Novel piperidinylamino-diarylpyrimidine derivatives with dual structural conformations as potent HIV-1 non-nucleoside reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 5.73 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 6.28 |
| CHEMBL3094518 | — | — | 1 | 6.02 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 5.60 |
| CHEMBL3094522 | — | — | 1 | 5.41 |
| CHEMBL3094524 | — | — | 1 | 5.34 |
| CHEMBL3091578 | — | — | 1 | - |
| CHEMBL929 | DELAVIRDINE MESYLATE | 4.0 | 1 | - |
| CHEMBL3094519 | — | — | 1 | - |
| CHEMBL3094523 | — | — | 1 | - |
| CHEMBL3094521 | — | — | 1 | - |
| CHEMBL3094520 | — | — | 1 | - |
| CHEMBL3094517 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL3094518 | — | EC50 | = | 950.0 | nM | 6.02 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3094522 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL3094524 | — | EC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL3091578 | — | EC50 | > | 6400.0 | nM | - |
| CHEMBL929 | DELAVIRDINE MESYLATE | EC50 | > | 36000.0 | nM | - |
| CHEMBL3094519 | — | EC50 | > | 28000.0 | nM | - |
| CHEMBL3094523 | — | EC50 | > | 206000.0 | nM | - |
| CHEMBL3094521 | — | EC50 | > | 11000.0 | nM | - |
| CHEMBL3094520 | — | EC50 | >= | 16000.0 | nM | - |
| CHEMBL3094517 | — | EC50 | >= | 1800.0 | nM | - |