Assay Detail
Functional
CHEMBL3095335
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 3B infected in human MT-4 cells assessed as protection against virus-induced cytopathicity after 5 days by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Novel piperidinylamino-diarylpyrimidine derivatives with dual structural conformations as potent HIV-1 non-nucleoside reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 7.07 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 8.15 |
| CHEMBL3094518 | — | — | 1 | 7.42 |
| CHEMBL3094524 | — | — | 1 | 7.33 |
| CHEMBL3094523 | — | — | 1 | 7.24 |
| CHEMBL3091578 | — | — | 1 | 7.11 |
| CHEMBL929 | DELAVIRDINE MESYLATE | 4.0 | 1 | 6.89 |
| CHEMBL3094522 | — | — | 1 | 6.89 |
| CHEMBL3094520 | — | — | 1 | 6.89 |
| CHEMBL3094517 | — | — | 1 | 6.85 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.77 |
| CHEMBL3094519 | — | — | 1 | 6.72 |
| CHEMBL3094521 | — | — | 1 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3094518 | — | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL3094524 | — | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL3094523 | — | EC50 | = | 58.0 | nM | 7.24 |
| CHEMBL3091578 | — | EC50 | = | 77.0 | nM | 7.11 |
| CHEMBL929 | DELAVIRDINE MESYLATE | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3094522 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3094520 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3094517 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3094519 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL3094521 | — | EC50 | = | 240.0 | nM | 6.62 |