Assay Detail
Binding
CHEMBL3095595
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Inhibition of human AChE using acetylthiocholine chloride as substrate preincubated for 15 mins by Ellman's method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel tacrine-ebselen hybrids with improved cholinesterase inhibitory, hydrogen peroxide and peroxynitrite scavenging activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.36 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3093791 | — | — | 1 | 7.82 |
| CHEMBL3093787 | — | — | 1 | 7.71 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3093791 | — | IC50 | = | 15.13 | nM | 7.82 |
| CHEMBL3093787 | — | IC50 | = | 19.52 | nM | 7.71 |
| CHEMBL95 | TACRINE | IC50 | = | 285.0 | nM | 6.54 |