Assay Detail
Binding
CHEMBL3095601
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Non competitive inhibition of human recombinant AChE using ATChCl as substrate by Lineweaver-Burk plot analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Preparation, in vitro evaluation and molecular modelling of pyridinium-quinolinium/isoquinolinium non-symmetrical bisquaternary cholinesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.48 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1669479 | AMBENONIUM DICHLORIDE | — | 1 | 8.22 |
| CHEMBL3093804 | — | — | 1 | 8.00 |
| CHEMBL464538 | — | — | 1 | 7.30 |
| CHEMBL3093802 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1669479 | AMBENONIUM DICHLORIDE | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL3093804 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL464538 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL3093802 | — | Ki | = | 400.0 | nM | 6.40 |