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Assay Detail

CHEMBL3095603

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human plasmatic BChE after 5 mins by Ellman's method
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Tissue Plasma
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Cholinesterase (CHEMBL1914)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Preparation, in vitro evaluation and molecular modelling of pyridinium-quinolinium/isoquinolinium non-symmetrical bisquaternary cholinesterase inhibitors.
Komloova M, Horova A, Hrabinova M, Jun D, Dolezal M, Dolezal M, Vinsova J, Kuca K, Musilek K.
Bioorg Med Chem Lett (2013) 23 : 6663 -6666
PubMed 24220173 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 5.85 6.46

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3093796 1 6.46
CHEMBL3093797 1 6.43
CHEMBL3093804 1 6.17
CHEMBL3093798 1 6.16
CHEMBL3093803 1 6.05
CHEMBL3093794 1 6.00
CHEMBL3093801 1 5.77
CHEMBL3093800 1 5.70
CHEMBL3093799 1 5.66
CHEMBL3093802 1 5.50
CHEMBL1669479 AMBENONIUM DICHLORIDE 1 5.17
CHEMBL3093795 1 5.11
CHEMBL464538 1 -
CHEMBL1128 EDROPHONIUM CHLORIDE 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3093796 IC50 = 350.0 nM 6.46
CHEMBL3093797 IC50 = 370.0 nM 6.43
CHEMBL3093804 IC50 = 680.0 nM 6.17
CHEMBL3093798 IC50 = 700.0 nM 6.16
CHEMBL3093803 IC50 = 900.0 nM 6.05
CHEMBL3093794 IC50 = 1000.0 nM 6.00
CHEMBL3093801 IC50 = 1700.0 nM 5.77
CHEMBL3093800 IC50 = 2000.0 nM 5.70
CHEMBL3093799 IC50 = 2200.0 nM 5.66
CHEMBL3093802 IC50 = 3200.0 nM 5.50
CHEMBL1669479 AMBENONIUM DICHLORIDE IC50 = 6800.0 nM 5.17
CHEMBL3093795 IC50 = 7700.0 nM 5.11
CHEMBL464538 IC50 = 354000.0 nM -
CHEMBL1128 EDROPHONIUM CHLORIDE IC50 = 1370000.0 nM -