Assay Detail
Binding
CHEMBL3095604
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant AChE after 5 mins by Ellman's method
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Preparation, in vitro evaluation and molecular modelling of pyridinium-quinolinium/isoquinolinium non-symmetrical bisquaternary cholinesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.26 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1669479 | AMBENONIUM DICHLORIDE | — | 1 | 9.15 |
| CHEMBL3093804 | — | — | 1 | 8.33 |
| CHEMBL3093802 | — | — | 1 | 8.30 |
| CHEMBL3093803 | — | — | 1 | 7.77 |
| CHEMBL3093797 | — | — | 1 | 7.70 |
| CHEMBL3093798 | — | — | 1 | 7.52 |
| CHEMBL464538 | — | — | 1 | 7.52 |
| CHEMBL3093796 | — | — | 1 | 7.40 |
| CHEMBL3093801 | — | — | 1 | 6.92 |
| CHEMBL3093795 | — | — | 1 | 6.85 |
| CHEMBL3093800 | — | — | 1 | 6.57 |
| CHEMBL3093799 | — | — | 1 | 6.27 |
| CHEMBL3093794 | — | — | 1 | 6.10 |
| CHEMBL1128 | EDROPHONIUM CHLORIDE | 4.0 | 1 | 5.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1669479 | AMBENONIUM DICHLORIDE | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL3093804 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL3093802 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3093803 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3093797 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3093798 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL464538 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3093796 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3093801 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3093795 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3093800 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL3093799 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL3093794 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1128 | EDROPHONIUM CHLORIDE | IC50 | = | 5170.0 | nM | 5.29 |