Assay Detail
Binding
CHEMBL3095672
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human 5-HT2B receptor expressed in HEK293 cells coexpressing EBNA assessed as inhibition of 5-HT-induced IP metabolism incubated for 20 mins prior to substrate addition measured after 20 mins by liquid scintillation counting analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293-EBNA |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of new carbonyl guanidine derivatives as novel dual 5-HT2B and 5-HT7 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.58 | 7.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3092759 | — | — | 1 | 7.71 |
| CHEMBL3092753 | — | — | 1 | 7.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3092759 | — | IC50 | = | 19.6 | nM | 7.71 |
| CHEMBL3092753 | — | IC50 | = | 36.4 | nM | 7.44 |