Assay Detail
Binding
CHEMBL3096083
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]CCPA from adenosine A1 receptor in rat brain cortex
59
Total Activities
59
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
1,3-Dialkyl-substituted tetrahydropyrimido[1,2-f]purine-2,4-diones as multiple target drugs for the potential treatment of neurodegenerative diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 59 | 6.04 | 6.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3093315 | — | — | 1 | 6.94 |
| CHEMBL3093310 | — | — | 1 | 6.87 |
| CHEMBL3093237 | — | — | 1 | 6.78 |
| CHEMBL3093322 | — | — | 1 | 6.77 |
| CHEMBL3093323 | — | — | 1 | 6.66 |
| CHEMBL3093332 | — | — | 1 | 6.64 |
| CHEMBL3093312 | — | — | 1 | 6.64 |
| CHEMBL3093331 | — | — | 1 | 6.50 |
| CHEMBL3093230 | — | — | 1 | 6.49 |
| CHEMBL241618 | — | — | 1 | 6.37 |
| CHEMBL3093330 | — | — | 1 | 6.33 |
| CHEMBL3093225 | — | — | 1 | 6.30 |
| CHEMBL3093317 | — | — | 1 | 6.30 |
| CHEMBL3093321 | — | — | 1 | 6.29 |
| CHEMBL3093325 | — | — | 1 | 6.26 |
| CHEMBL3093313 | — | — | 1 | 6.26 |
| CHEMBL3093316 | — | — | 1 | 6.20 |
| CHEMBL413079 | — | — | 1 | 6.05 |
| CHEMBL3093320 | — | — | 1 | 6.00 |
| CHEMBL3091482 | — | — | 1 | 5.97 |
| CHEMBL3093231 | — | — | 1 | 5.97 |
| CHEMBL3093311 | — | — | 1 | 5.97 |
| CHEMBL3093329 | — | — | 1 | 5.92 |
| CHEMBL3093224 | — | — | 1 | 5.91 |
| CHEMBL3093238 | — | — | 1 | 5.75 |
| CHEMBL3093314 | — | — | 1 | 5.74 |
| CHEMBL239230 | — | — | 1 | 5.52 |
| CHEMBL3093318 | — | — | 1 | 5.50 |
| CHEMBL3093236 | — | — | 1 | 5.40 |
| CHEMBL3093232 | — | — | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3093315 | — | Ki | = | 114.0 | nM | 6.94 |
| CHEMBL3093310 | — | Ki | = | 135.0 | nM | 6.87 |
| CHEMBL3093237 | — | Ki | = | 165.0 | nM | 6.78 |
| CHEMBL3093322 | — | Ki | = | 169.0 | nM | 6.77 |
| CHEMBL3093323 | — | Ki | = | 219.0 | nM | 6.66 |
| CHEMBL3093332 | — | Ki | = | 228.0 | nM | 6.64 |
| CHEMBL3093312 | — | Ki | = | 227.0 | nM | 6.64 |
| CHEMBL3093331 | — | Ki | = | 313.0 | nM | 6.50 |
| CHEMBL3093230 | — | Ki | = | 321.0 | nM | 6.49 |
| CHEMBL241618 | — | Ki | = | 432.0 | nM | 6.37 |
| CHEMBL3093330 | — | Ki | = | 469.0 | nM | 6.33 |
| CHEMBL3093225 | — | Ki | = | 506.0 | nM | 6.30 |
| CHEMBL3093317 | — | Ki | = | 501.0 | nM | 6.30 |
| CHEMBL3093321 | — | Ki | = | 515.0 | nM | 6.29 |
| CHEMBL3093313 | — | Ki | = | 555.0 | nM | 6.26 |
| CHEMBL3093325 | — | Ki | = | 545.0 | nM | 6.26 |
| CHEMBL3093316 | — | Ki | = | 632.0 | nM | 6.20 |
| CHEMBL413079 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL3093320 | — | Ki | = | 990.0 | nM | 6.00 |
| CHEMBL3091482 | — | Ki | = | 1070.0 | nM | 5.97 |
| CHEMBL3093231 | — | Ki | = | 1070.0 | nM | 5.97 |
| CHEMBL3093311 | — | Ki | = | 1060.0 | nM | 5.97 |
| CHEMBL3093329 | — | Ki | = | 1190.0 | nM | 5.92 |
| CHEMBL3093224 | — | Ki | = | 1240.0 | nM | 5.91 |
| CHEMBL3093238 | — | Ki | = | 1760.0 | nM | 5.75 |
| CHEMBL3093314 | — | Ki | = | 1830.0 | nM | 5.74 |
| CHEMBL239230 | — | Ki | = | 3030.0 | nM | 5.52 |
| CHEMBL3093318 | — | Ki | = | 3140.0 | nM | 5.50 |
| CHEMBL3093236 | — | Ki | = | 4010.0 | nM | 5.40 |
| CHEMBL3093232 | — | Ki | = | 4420.0 | nM | 5.36 |
| CHEMBL3093333 | — | Ki | = | 5220.0 | nM | 5.28 |
| CHEMBL3093239 | — | Ki | = | 7240.0 | nM | 5.14 |
| CHEMBL282038 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL113 | CAFFEINE | Ki | = | 41000.0 | nM | 4.39 |
| CHEMBL3093240 | — | Ki | > | 1500.0 | nM | - |
| CHEMBL3093324 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3093214 | — | Ki | > | 1500.0 | nM | - |
| CHEMBL3093215 | — | Ki | > | 1500.0 | nM | - |
| CHEMBL3093216 | — | Ki | > | 1500.0 | nM | - |
| CHEMBL3093217 | — | Ki | > | 1500.0 | nM | - |
| CHEMBL3093218 | — | Ki | > | 1500.0 | nM | - |
| CHEMBL3093219 | — | Ki | > | 1500.0 | nM | - |
| CHEMBL3093220 | — | Ki | > | 1500.0 | nM | - |
| CHEMBL3093221 | — | Ki | > | 1500.0 | nM | - |
| CHEMBL3091481 | — | Ki | > | 1500.0 | nM | - |
| CHEMBL3093222 | — | Ki | > | 1500.0 | nM | - |
| CHEMBL3093241 | — | Ki | > | 1500.0 | nM | - |
| CHEMBL3093226 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3093328 | — | Ki | > | 25000.0 | nM | - |
| CHEMBL3093319 | — | Ki | > | 10000.0 | nM | - |