Assay Detail
Binding
CHEMBL3096170
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 6xHis-tagged recombinant DPP7 (unknown origin) expressed in baculovirus expression system assessed as hydrolysis of Nle-Pro-aminomethylcoumarin after 20 mins by fluorometric assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of pyrrolidine-2-carbonitrile and 4-fluoropyrrolidine-2-carbonitrile derivatives as dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 5.48 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3093910 | — | — | 1 | 6.92 |
| CHEMBL3093907 | — | — | 1 | 6.10 |
| CHEMBL3093914 | — | — | 1 | 6.05 |
| CHEMBL3093909 | — | — | 1 | 5.97 |
| CHEMBL3093915 | — | — | 1 | 5.89 |
| CHEMBL3093900 | — | — | 1 | 5.88 |
| CHEMBL3093905 | — | — | 1 | 5.84 |
| CHEMBL3093903 | — | — | 1 | 5.84 |
| CHEMBL3093923 | — | — | 1 | 5.80 |
| CHEMBL3093921 | — | — | 1 | 5.77 |
| CHEMBL3093901 | — | — | 1 | 5.77 |
| CHEMBL3093904 | — | — | 1 | 5.76 |
| CHEMBL3093913 | — | — | 1 | 5.74 |
| CHEMBL3093922 | — | — | 1 | 5.67 |
| CHEMBL3091488 | — | — | 1 | 5.59 |
| CHEMBL3093896 | — | — | 1 | 5.39 |
| CHEMBL200347 | — | — | 1 | 5.38 |
| CHEMBL3093920 | — | — | 1 | 5.33 |
| CHEMBL3093917 | — | — | 1 | 5.26 |
| CHEMBL3093918 | — | — | 1 | 5.23 |
| CHEMBL3093925 | — | — | 1 | 5.21 |
| CHEMBL3093924 | — | — | 1 | 5.15 |
| CHEMBL3093919 | — | — | 1 | 5.06 |
| CHEMBL3093902 | — | — | 1 | 4.84 |
| CHEMBL3093906 | — | — | 1 | 4.41 |
| CHEMBL201268 | — | — | 1 | 4.07 |
| CHEMBL3093911 | — | — | 1 | 4.00 |
| CHEMBL3093916 | — | — | 1 | - |
| CHEMBL142703 | VILDAGLIPTIN | 4.0 | 1 | - |
| CHEMBL3093912 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3093910 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3093907 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3093914 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3093909 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL3093915 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL3093900 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL3093905 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL3093903 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL3093923 | — | IC50 | = | 1570.0 | nM | 5.80 |
| CHEMBL3093921 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3093901 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3093904 | — | IC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL3093913 | — | IC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL3093922 | — | IC50 | = | 2140.0 | nM | 5.67 |
| CHEMBL3091488 | — | IC50 | = | 2540.0 | nM | 5.59 |
| CHEMBL3093896 | — | IC50 | = | 4110.0 | nM | 5.39 |
| CHEMBL200347 | — | IC50 | = | 4130.0 | nM | 5.38 |
| CHEMBL3093920 | — | IC50 | = | 4670.0 | nM | 5.33 |
| CHEMBL3093917 | — | IC50 | = | 5440.0 | nM | 5.26 |
| CHEMBL3093918 | — | IC50 | = | 5880.0 | nM | 5.23 |
| CHEMBL3093925 | — | IC50 | = | 6220.0 | nM | 5.21 |
| CHEMBL3093924 | — | IC50 | = | 7010.0 | nM | 5.15 |
| CHEMBL3093919 | — | IC50 | = | 8780.0 | nM | 5.06 |
| CHEMBL3093902 | — | IC50 | = | 14520.0 | nM | 4.84 |
| CHEMBL3093906 | — | IC50 | = | 39090.0 | nM | 4.41 |
| CHEMBL201268 | — | IC50 | = | 84430.0 | nM | 4.07 |
| CHEMBL3093911 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL3093916 | — | IC50 | = | 296900.0 | nM | - |
| CHEMBL142703 | VILDAGLIPTIN | IC50 | - | — | - | |
| CHEMBL3093912 | — | IC50 | = | 102000.0 | nM | - |
| CHEMBL3093897 | — | IC50 | - | — | - | |
| CHEMBL3093898 | — | IC50 | - | — | - | |
| CHEMBL3093899 | — | IC50 | - | — | - |