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Assay Detail

CHEMBL3096273

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HCT116 cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HCT-116
Confidence 1 — Organism
Curated By Autocuration

Target

HCT-116 (CHEMBL394)
Type CELL-LINE
Organism Homo sapiens

Publication

Novel Mps1 kinase inhibitors: from purine to pyrrolopyrimidine and quinazoline leads.
Bursavich MG, Dastrup D, Shenderovich M, Yager KM, Cimbora DM, Williams B, Kumar DV.
Bioorg Med Chem Lett (2013) 23 : 6829 -6833
PubMed 24183538 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 5.95 7.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2047959 1 7.96
CHEMBL2047943 1 7.64
CHEMBL3092030 1 6.12
CHEMBL3092039 1 6.09
CHEMBL3092035 1 6.07
CHEMBL3092026 1 5.82
CHEMBL3092038 1 5.80
CHEMBL3092037 1 5.76
CHEMBL3092025 1 5.70
CHEMBL3092036 1 5.20
CHEMBL3092028 1 5.12
CHEMBL3092029 1 5.07
CHEMBL3092032 1 5.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2047959 IC50 = 11.0 nM 7.96
CHEMBL2047943 IC50 = 23.0 nM 7.64
CHEMBL3092030 IC50 = 750.0 nM 6.12
CHEMBL3092039 IC50 = 810.0 nM 6.09
CHEMBL3092035 IC50 = 850.0 nM 6.07
CHEMBL3092026 IC50 = 1500.0 nM 5.82
CHEMBL3092038 IC50 = 1580.0 nM 5.80
CHEMBL3092037 IC50 = 1740.0 nM 5.76
CHEMBL3092025 IC50 = 2000.0 nM 5.70
CHEMBL3092036 IC50 = 6320.0 nM 5.20
CHEMBL3092028 IC50 = 7500.0 nM 5.12
CHEMBL3092029 IC50 = 8600.0 nM 5.07
CHEMBL3092032 IC50 = 10000.0 nM 5.00