Assay Detail
Binding
CHEMBL3096356
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of C-Raf (unknown origin) assessed as phosphorylation of MEK1 after 45 mins by TR-FRET assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
RAF proto-oncogene serine/threonine-protein kinase (CHEMBL1906) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Fluorine Scanning by Nonselective Fluorination: Enhancing Raf/MEK Inhibition while Keeping Physicochemical Properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.85 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3086065 | — | — | 1 | 8.10 |
| CHEMBL3092191 | — | — | 1 | 8.10 |
| CHEMBL3092185 | — | — | 1 | 7.89 |
| CHEMBL3092195 | — | — | 1 | 7.64 |
| CHEMBL3092178 | — | — | 1 | 7.60 |
| CHEMBL3092181 | — | — | 1 | 7.26 |
| CHEMBL3092176 | — | — | 1 | 7.20 |
| CHEMBL3092180 | — | — | 1 | 7.16 |
| CHEMBL3092179 | — | — | 1 | 7.11 |
| CHEMBL3092193 | — | — | 1 | 6.92 |
| CHEMBL3092187 | — | — | 1 | 6.92 |
| CHEMBL3092186 | — | — | 1 | 6.75 |
| CHEMBL3092188 | — | — | 1 | 6.66 |
| CHEMBL3092189 | — | — | 1 | 6.52 |
| CHEMBL3092182 | — | — | 1 | 6.28 |
| CHEMBL3092183 | — | — | 1 | 6.08 |
| CHEMBL3092184 | — | — | 1 | 5.96 |
| CHEMBL3092196 | — | — | 1 | 5.82 |
| CHEMBL3092190 | — | — | 1 | 5.62 |
| CHEMBL3092177 | — | — | 1 | 5.44 |
| CHEMBL3092192 | — | — | 1 | - |
| CHEMBL3092194 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3086065 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3092191 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3092185 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3092195 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3092178 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3092181 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL3092176 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL3092180 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3092179 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL3092193 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3092187 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3092186 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3092188 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL3092189 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3092182 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL3092183 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL3092184 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3092196 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3092190 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL3092177 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL3092192 | — | IC50 | - | — | - | |
| CHEMBL3092194 | — | IC50 | > | 10000.0 | nM | - |