Assay Detail
Binding
CHEMBL3096508
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Inhibition of human cathepsin-L using Z-Val-Val-Arg-AMC as substrate up to 20 mins by fluorescence assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of potent and selective cathepsin S inhibitors containing different central cyclic scaffolds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.06 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3093826 | — | — | 1 | 5.72 |
| CHEMBL3093828 | — | — | 1 | 5.58 |
| CHEMBL3093822 | — | — | 1 | 5.57 |
| CHEMBL3093823 | — | — | 1 | 5.39 |
| CHEMBL3093825 | — | — | 1 | 5.38 |
| CHEMBL3093829 | — | — | 1 | 5.34 |
| CHEMBL3093827 | — | — | 1 | 5.33 |
| CHEMBL3093934 | — | — | 1 | 5.17 |
| CHEMBL3093935 | — | — | 1 | 5.08 |
| CHEMBL3093940 | — | — | 1 | 4.93 |
| CHEMBL3093947 | — | — | 1 | 4.91 |
| CHEMBL3093926 | — | — | 1 | 4.80 |
| CHEMBL3093930 | — | — | 1 | 4.79 |
| CHEMBL3093928 | — | — | 1 | 4.77 |
| CHEMBL3093824 | — | — | 1 | 4.65 |
| CHEMBL3093931 | — | — | 1 | 4.60 |
| CHEMBL3093936 | — | — | 1 | 4.53 |
| CHEMBL3093929 | — | — | 1 | 4.47 |
| CHEMBL3093927 | — | — | 1 | - |
| CHEMBL3093932 | — | — | 1 | - |
| CHEMBL3093933 | — | — | 1 | - |
| CHEMBL3093948 | — | — | 1 | - |
| CHEMBL3093946 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3093826 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL3093828 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3093822 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL3093823 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL3093825 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL3093829 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL3093827 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL3093934 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL3093935 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL3093940 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL3093947 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL3093926 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL3093930 | — | IC50 | = | 16200.0 | nM | 4.79 |
| CHEMBL3093928 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL3093824 | — | IC50 | = | 22200.0 | nM | 4.65 |
| CHEMBL3093931 | — | IC50 | = | 24900.0 | nM | 4.60 |
| CHEMBL3093936 | — | IC50 | = | 29700.0 | nM | 4.53 |
| CHEMBL3093929 | — | IC50 | = | 33600.0 | nM | 4.47 |
| CHEMBL3093927 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3093932 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3093933 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3093948 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3093946 | — | IC50 | > | 25000.0 | nM | - |