Assay Detail
Binding
CHEMBL3096514
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Inhibition of human cathepsin-S using Z-Val-Val-Arg-AMC as substrate up to 20 mins by fluorescence assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of potent and selective cathepsin S inhibitors containing different central cyclic scaffolds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 8.35 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3093935 | — | — | 1 | 9.52 |
| CHEMBL3093822 | — | — | 1 | 9.40 |
| CHEMBL3093941 | — | — | 1 | 9.30 |
| CHEMBL3093826 | — | — | 1 | 9.30 |
| CHEMBL3093940 | — | — | 1 | 9.15 |
| CHEMBL3093947 | — | — | 1 | 9.15 |
| CHEMBL3093825 | — | — | 1 | 9.10 |
| CHEMBL3093934 | — | — | 1 | 9.10 |
| CHEMBL3093942 | — | — | 1 | 9.05 |
| CHEMBL3093829 | — | — | 1 | 9.00 |
| CHEMBL3093936 | — | — | 1 | 9.00 |
| CHEMBL3093823 | — | — | 1 | 9.00 |
| CHEMBL3093928 | — | — | 1 | 8.70 |
| CHEMBL3093827 | — | — | 1 | 8.70 |
| CHEMBL3093932 | — | — | 1 | 8.70 |
| CHEMBL3093946 | — | — | 1 | 8.52 |
| CHEMBL3093824 | — | — | 1 | 8.52 |
| CHEMBL3093948 | — | — | 1 | 8.40 |
| CHEMBL3093926 | — | — | 1 | 8.40 |
| CHEMBL3093931 | — | — | 1 | 8.22 |
| CHEMBL3093930 | — | — | 1 | 8.15 |
| CHEMBL3093929 | — | — | 1 | 8.00 |
| CHEMBL3093828 | — | — | 1 | 7.96 |
| CHEMBL3093944 | — | — | 1 | 7.92 |
| CHEMBL3093933 | — | — | 1 | 7.89 |
| CHEMBL3093945 | — | — | 1 | 7.75 |
| CHEMBL3093927 | — | — | 1 | 7.58 |
| CHEMBL3093939 | — | — | 1 | 6.64 |
| CHEMBL3093943 | — | — | 1 | 6.57 |
| CHEMBL3093937 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3093935 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL3093822 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL3093941 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL3093826 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL3093940 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL3093947 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL3093825 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL3093934 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL3093942 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL3093829 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3093936 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3093823 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3093928 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3093827 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3093932 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3093946 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3093824 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3093948 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3093926 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3093931 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3093930 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3093929 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3093828 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3093944 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3093933 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3093945 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3093927 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3093939 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL3093943 | — | IC50 | = | 271.0 | nM | 6.57 |
| CHEMBL3093937 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL3093938 | — | IC50 | = | 830.0 | nM | 6.08 |