Assay Detail
Binding
CHEMBL3096525
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human full length PDE2A3 expressed in insect SF-21 cells using [3H]-cGMP as substrate by scintillation proximity assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SF-21 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
cGMP-dependent 3',5'-cyclic phosphodiesterase (CHEMBL2652) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
PDE2 inhibition: potential for the treatment of cognitive disorders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.58 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3092562 | PF-05180999 | 1.0 | 1 | 9.00 |
| CHEMBL2381192 | — | — | 1 | 8.70 |
| CHEMBL3092561 | — | — | 1 | 8.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3092562 | PF-05180999 | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2381192 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3092561 | — | IC50 | = | 9.0 | nM | 8.05 |