Assay Detail
Functional
CHEMBL3096863
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Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by WST-1 assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Nicotinamide phosphoribosyltransferase inhibitors, design, preparation, and structure-activity relationship.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.16 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3094255 | — | — | 1 | 8.72 |
| CHEMBL3094257 | — | — | 1 | 8.44 |
| CHEMBL3094234 | — | — | 1 | 8.28 |
| CHEMBL566757 | DAPORINAD | 2.0 | 1 | 7.96 |
| CHEMBL3094228 | — | — | 1 | 7.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3094255 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL3094257 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL3094234 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL566757 | DAPORINAD | IC50 | = | 10.9 | nM | 7.96 |
| CHEMBL3094228 | — | IC50 | = | 39.0 | nM | 7.41 |