Assay Detail
Binding
CHEMBL3096916
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Agonist activity at glucocorticoid receptor in HFF assessed as inhibition of IL-1-induced IL-6 production after 24 hrs
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Function-regulating pharmacophores in a sulfonamide class of glucocorticoid receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 7.68 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL384467 | DEXAMETHASONE | 4.0 | 1 | 9.30 |
| CHEMBL3093463 | — | — | 1 | 8.15 |
| CHEMBL3093462 | — | — | 1 | 8.00 |
| CHEMBL3093453 | — | — | 1 | 7.82 |
| CHEMBL3093452 | — | — | 1 | 7.35 |
| CHEMBL3093441 | — | — | 1 | 7.25 |
| CHEMBL3093440 | — | — | 1 | 6.92 |
| CHEMBL3093446 | — | — | 1 | 6.68 |
| CHEMBL3093461 | — | — | 1 | - |
| CHEMBL3093456 | — | — | 1 | - |
| CHEMBL3093455 | — | — | 1 | - |
| CHEMBL3093447 | — | — | 1 | - |
| CHEMBL3093445 | — | — | 1 | - |
| CHEMBL3093444 | — | — | 1 | - |
| CHEMBL3093443 | — | — | 1 | - |
| CHEMBL3093442 | — | — | 1 | - |
| CHEMBL395795 | — | — | 1 | - |
| CHEMBL396029 | — | — | 1 | - |
| CHEMBL3093451 | — | — | 1 | - |
| CHEMBL3093450 | — | — | 1 | - |
| CHEMBL3093449 | — | — | 1 | - |
| CHEMBL3093460 | — | — | 1 | - |
| CHEMBL3093459 | — | — | 1 | - |
| CHEMBL3093458 | — | — | 1 | - |
| CHEMBL3093457 | — | — | 1 | - |
| CHEMBL3093454 | — | — | 1 | - |
| CHEMBL3093448 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL384467 | DEXAMETHASONE | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL3093463 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3093462 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3093453 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3093452 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL3093441 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL3093440 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3093446 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3093461 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL3093456 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL3093455 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL3093447 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL3093445 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL3093444 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL3093443 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL3093442 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL395795 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL396029 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL3093451 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3093450 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3093449 | — | IC50 | - | — | - | |
| CHEMBL3093460 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3093459 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3093458 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3093457 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3093454 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3093448 | — | IC50 | > | 10000.0 | nM | - |