Assay Detail
Binding
CHEMBL3096919
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of TAMRA-labeled dexamethasone from glucocorticoid receptor (unknown origin) by fluorescence polarization competitive binding assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Function-regulating pharmacophores in a sulfonamide class of glucocorticoid receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 7.68 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3093463 | — | — | 1 | 9.00 |
| CHEMBL3093461 | — | — | 1 | 8.70 |
| CHEMBL3093462 | — | — | 1 | 8.70 |
| CHEMBL384467 | DEXAMETHASONE | 4.0 | 1 | 8.46 |
| CHEMBL3093440 | — | — | 1 | 8.30 |
| CHEMBL3093453 | — | — | 1 | 8.30 |
| CHEMBL3093441 | — | — | 1 | 8.00 |
| CHEMBL3093446 | — | — | 1 | 8.00 |
| CHEMBL3093452 | — | — | 1 | 8.00 |
| CHEMBL3093443 | — | — | 1 | 7.82 |
| CHEMBL3093444 | — | — | 1 | 7.82 |
| CHEMBL3093456 | — | — | 1 | 7.82 |
| CHEMBL3093445 | — | — | 1 | 7.75 |
| CHEMBL3093448 | — | — | 1 | 7.70 |
| CHEMBL3093460 | — | — | 1 | 7.70 |
| CHEMBL3093454 | — | — | 1 | 7.60 |
| CHEMBL3093442 | — | — | 1 | 7.46 |
| CHEMBL3093447 | — | — | 1 | 7.43 |
| CHEMBL395795 | — | — | 1 | 7.40 |
| CHEMBL3093457 | — | — | 1 | 7.22 |
| CHEMBL396029 | — | — | 1 | 7.19 |
| CHEMBL3093458 | — | — | 1 | 7.02 |
| CHEMBL3093459 | — | — | 1 | 6.68 |
| CHEMBL3093451 | — | — | 1 | 6.55 |
| CHEMBL3093450 | — | — | 1 | 6.50 |
| CHEMBL3093455 | — | — | 1 | 6.47 |
| CHEMBL3093449 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3093463 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3093461 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3093462 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL384467 | DEXAMETHASONE | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL3093440 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3093453 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3093441 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3093446 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3093452 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3093443 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3093444 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3093456 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3093445 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3093448 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3093460 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3093454 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3093442 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL3093447 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL395795 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3093457 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL396029 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL3093458 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL3093459 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3093451 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL3093450 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL3093455 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL3093449 | — | IC50 | > | 10000.0 | nM | - |