Assay Detail
Binding
CHEMBL3097100
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]WIN 35428 from dopamine transporter in rat striatum after 120 mins by liquid scintillation counting analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Chlorophenylpiperazine analogues as high affinity dopamine transporter ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.58 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL113621 | — | — | 1 | 10.40 |
| CHEMBL3093268 | — | — | 1 | 9.89 |
| CHEMBL3093269 | — | — | 1 | 8.22 |
| CHEMBL3093270 | — | — | 1 | 6.32 |
| CHEMBL112125 | — | — | 1 | 5.58 |
| CHEMBL145867 | — | — | 1 | 5.04 |
| CHEMBL325262 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL113621 | — | Ki | = | 0.04 | nM | 10.40 |
| CHEMBL3093268 | — | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL3093269 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL3093270 | — | Ki | = | 482.0 | nM | 6.32 |
| CHEMBL112125 | — | Ki | = | 2647.0 | nM | 5.58 |
| CHEMBL145867 | — | Ki | = | 9148.0 | nM | 5.04 |
| CHEMBL325262 | — | Ki | > | 10000.0 | nM | - |