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Assay Detail

CHEMBL3097433

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]CP-55,940 from human recombinant cannabinoid CB2 receptor expressed in CHO cells
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Cannabinoid receptor 2 (CHEMBL253)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Development of fluorinated CB(2) receptor agonists for PET studies.
Lueg C, Schepmann D, Günther R, Brust P, Wünsch B.
Bioorg Med Chem (2013) 21 : 7481 -7498
PubMed 24139843 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 20 6.79 8.24

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3093378 1 8.24
CHEMBL499324 1 8.16
CHEMBL307696 1 7.75
CHEMBL559612 CP-55940 1 7.57
CHEMBL3093366 1 7.48
CHEMBL3093379 1 7.39
CHEMBL188 WIN-552122 1 7.16
CHEMBL3093369 1 7.02
CHEMBL3093367 1 6.71
CHEMBL3093380 1 6.54
CHEMBL3093360 1 6.43
CHEMBL3093381 1 6.42
CHEMBL3093382 1 6.32
CHEMBL3093365 1 6.31
CHEMBL3093389 1 6.25
CHEMBL3093372 1 6.23
CHEMBL3093383 1 6.07
CHEMBL3093362 1 6.00
CHEMBL3093361 1 5.96
CHEMBL3093384 1 5.75

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3093378 Ki = 5.8 nM 8.24
CHEMBL499324 Ki = 6.98 nM 8.16
CHEMBL307696 Ki = 18.0 nM 7.75
CHEMBL559612 CP-55940 Ki = 27.0 nM 7.57
CHEMBL3093366 Ki = 33.0 nM 7.48
CHEMBL3093379 Ki = 41.0 nM 7.39
CHEMBL188 WIN-552122 Ki = 70.0 nM 7.16
CHEMBL3093369 Ki = 96.0 nM 7.02
CHEMBL3093367 Ki = 195.0 nM 6.71
CHEMBL3093380 Ki = 291.0 nM 6.54
CHEMBL3093360 Ki = 367.0 nM 6.43
CHEMBL3093381 Ki = 377.0 nM 6.42
CHEMBL3093382 Ki = 476.0 nM 6.32
CHEMBL3093365 Ki = 486.0 nM 6.31
CHEMBL3093389 Ki = 559.0 nM 6.25
CHEMBL3093372 Ki = 584.0 nM 6.23
CHEMBL3093383 Ki = 858.0 nM 6.07
CHEMBL3093362 Ki = 990.0 nM 6.00
CHEMBL3093361 Ki = 1100.0 nM 5.96
CHEMBL3093384 Ki = 1800.0 nM 5.75