Assay Detail
Binding
CHEMBL3097485
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Inverse agonist activity at GAL4-fused human RORa expressed in HEK293T cells assessed as suppression of basal transcriptional activity after 20 hrs by dual-glo luciferase reporter gene assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-based design of substituted hexafluoroisopropanol-arylsulfonamides as modulators of RORc.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.25 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2326845 | — | — | 1 | 5.30 |
| CHEMBL62136 | T091317 | — | 1 | 5.30 |
| CHEMBL3094369 | — | — | 1 | 5.22 |
| CHEMBL3094367 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2326845 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL62136 | T091317 | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3094369 | — | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL3094367 | — | EC50 | = | 7000.0 | nM | 5.16 |