Assay Detail
Binding
CHEMBL3097526
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Inhibition of recombinant human IDO1 expressed in Escherichia coli EC538 using L-tryptophan as substrate after 1 hr
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and characterisation of hydrazines as inhibitors of the immune suppressive enzyme, indoleamine 2,3-dioxygenase 1 (IDO1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.84 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL456807 | PHENYLHYDRAZINE | — | 1 | 6.60 |
| CHEMBL3092383 | — | — | 1 | 5.82 |
| CHEMBL1933308 | — | — | 1 | 5.10 |
| CHEMBL508112 | BENZOTHIAZYL DISULFIDE | — | 1 | - |
| CHEMBL111654 | 2-MERCAPTOBENZOTHIAZOLE | — | 1 | - |
| CHEMBL318275 | — | — | 1 | - |
| CHEMBL510309 | BENZO[D]THIAZOLE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL456807 | PHENYLHYDRAZINE | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL3092383 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1933308 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL508112 | BENZOTHIAZYL DISULFIDE | IC50 | > | 500000.0 | nM | - |
| CHEMBL111654 | 2-MERCAPTOBENZOTHIAZOLE | IC50 | = | 126000.0 | nM | - |
| CHEMBL318275 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL510309 | BENZO[D]THIAZOLE | IC50 | = | 652000.0 | nM | - |