Assay Detail
Binding
CHEMBL3097748
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant DYRK2 expressed in Escherichia coli using GRSRSRSRSRSR as substrate
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity tyrosine-phosphorylation-regulated kinase 2 (CHEMBL4376) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Chemical synthesis and biological validation of immobilized protein kinase inhibitory Leucettines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.79 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3092863 | — | — | 1 | 6.89 |
| CHEMBL3092862 | — | — | 1 | 6.82 |
| CHEMBL1802358 | — | — | 1 | 6.66 |
| CHEMBL3092864 | — | — | 1 | - |
| CHEMBL3092861 | — | — | 1 | - |
| CHEMBL3092860 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3092863 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3092862 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1802358 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL3092864 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3092861 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3092860 | — | IC50 | > | 10000.0 | nM | - |