Assay Detail
Functional
CHEMBL3097946
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against enfuvirtide-resistant HIV-1 NL4-3 harboring gp41 (36G)V38E/N42S mutation infected in human MT2 cells assessed as inhibition of p24 antigen production after 4 days by ELISA
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Small molecule fusion inhibitors: design, synthesis and biological evaluation of (Z)-3-(5-(3-benzyl-4-oxo-2-thioxothiazolidinylidene)methyl)-N-(3-carboxy-4-hydroxy)phenyl-2,5-dimethylpyrroles and related derivatives targeting HIV-1 gp41.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.53 | 5.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3092874 | — | — | 1 | 5.57 |
| CHEMBL3092872 | — | — | 1 | 5.56 |
| CHEMBL3092878 | — | — | 1 | 5.47 |
| CHEMBL525076 | ENFUVIRTIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3092874 | — | IC50 | = | 2670.0 | nM | 5.57 |
| CHEMBL3092872 | — | IC50 | = | 2746.0 | nM | 5.56 |
| CHEMBL3092878 | — | IC50 | = | 3367.0 | nM | 5.47 |
| CHEMBL525076 | ENFUVIRTIDE | IC50 | > | 2000.0 | nM | - |