Assay Detail
Functional
CHEMBL3097953
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 3B infected in human MT2 cells assessed as inhibition of p24 antigen production after 4 days by ELISA
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Small molecule fusion inhibitors: design, synthesis and biological evaluation of (Z)-3-(5-(3-benzyl-4-oxo-2-thioxothiazolidinylidene)methyl)-N-(3-carboxy-4-hydroxy)phenyl-2,5-dimethylpyrroles and related derivatives targeting HIV-1 gp41.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 5.08 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3092878 | — | — | 1 | 6.52 |
| CHEMBL214344 | — | — | 1 | 6.16 |
| CHEMBL3092874 | — | — | 1 | 6.05 |
| CHEMBL3092872 | — | — | 1 | 5.82 |
| CHEMBL3092867 | — | — | 1 | 5.50 |
| CHEMBL3092875 | — | — | 1 | 5.41 |
| CHEMBL3092868 | — | — | 1 | 5.21 |
| CHEMBL3092873 | — | — | 1 | 5.15 |
| CHEMBL3092879 | — | — | 1 | 4.92 |
| CHEMBL3092865 | — | — | 1 | 4.82 |
| CHEMBL3092869 | — | — | 1 | 4.76 |
| CHEMBL3092882 | — | — | 1 | 4.72 |
| CHEMBL3092871 | — | — | 1 | 4.70 |
| CHEMBL3092877 | — | — | 1 | 4.63 |
| CHEMBL3092880 | — | — | 1 | 4.54 |
| CHEMBL3092876 | — | — | 1 | 4.49 |
| CHEMBL3092866 | — | — | 1 | 4.45 |
| CHEMBL3092881 | — | — | 1 | 4.39 |
| CHEMBL3092870 | — | — | 1 | 4.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3092878 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL214344 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3092874 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3092872 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3092867 | — | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL3092875 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL3092868 | — | EC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL3092873 | — | EC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL3092879 | — | EC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL3092865 | — | EC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL3092869 | — | EC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL3092882 | — | EC50 | = | 19100.0 | nM | 4.72 |
| CHEMBL3092871 | — | EC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL3092877 | — | EC50 | = | 23500.0 | nM | 4.63 |
| CHEMBL3092880 | — | EC50 | = | 29100.0 | nM | 4.54 |
| CHEMBL3092876 | — | EC50 | = | 32400.0 | nM | 4.49 |
| CHEMBL3092866 | — | EC50 | = | 35600.0 | nM | 4.45 |
| CHEMBL3092881 | — | EC50 | = | 41100.0 | nM | 4.39 |
| CHEMBL3092870 | — | EC50 | = | 42700.0 | nM | 4.37 |