Assay Detail
Functional
CHEMBL3100270
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Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and SAR study of a novel series of dopamine receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 6.84 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3099222 | — | — | 1 | 7.72 |
| CHEMBL1303 | ROTIGOTINE | 4.0 | 1 | 7.55 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 7.41 |
| CHEMBL3099236 | — | — | 1 | 7.13 |
| CHEMBL3098131 | — | — | 1 | 7.08 |
| CHEMBL3099230 | — | — | 1 | 7.05 |
| CHEMBL3099225 | — | — | 1 | 6.92 |
| CHEMBL3099234 | — | — | 1 | 6.82 |
| CHEMBL3099226 | — | — | 1 | 6.82 |
| CHEMBL3099231 | — | — | 1 | 6.68 |
| CHEMBL3099235 | — | — | 1 | 6.64 |
| CHEMBL3099227 | — | — | 1 | 6.48 |
| CHEMBL3099232 | — | — | 1 | 6.44 |
| CHEMBL3099239 | — | — | 1 | 6.40 |
| CHEMBL3099233 | — | — | 1 | 5.41 |
| CHEMBL3099224 | — | — | 1 | - |
| CHEMBL3099228 | — | — | 1 | - |
| CHEMBL3099223 | — | — | 1 | - |
| CHEMBL3099229 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3099222 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1303 | ROTIGOTINE | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL59 | DOPAMINE | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3099236 | — | EC50 | = | 74.0 | nM | 7.13 |
| CHEMBL3098131 | — | EC50 | = | 83.0 | nM | 7.08 |
| CHEMBL3099230 | — | EC50 | = | 89.0 | nM | 7.05 |
| CHEMBL3099225 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3099234 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3099226 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3099231 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3099235 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL3099227 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL3099232 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL3099239 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3099233 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL3099224 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3099228 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3099223 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3099229 | — | EC50 | > | 10000.0 | nM | - |