Assay Detail
Binding
CHEMBL3100398
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at guinea pig trachea beta2-adrenergic receptor assessed as relaxation of histamine-induced tracheal ring contraction
17
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Trachea |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of dual pharmacology β2-adrenoceptor agonists and PDE4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 8.43 | 9.90 |
| Activity | 5 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1363 | ARFORMOTEROL | 4.0 | 2 | 9.90 |
| CHEMBL3099249 | — | — | 3 | 9.00 |
| CHEMBL3099248 | — | — | 3 | 8.30 |
| CHEMBL3099250 | — | — | 3 | 8.00 |
| CHEMBL3099251 | — | — | 3 | 7.90 |
| CHEMBL434 | ISOPROTERENOL | 4.0 | 3 | 7.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1363 | ARFORMOTEROL | EC50 | = | 0.1259 | nM | 9.90 |
| CHEMBL1363 | ARFORMOTEROL | EC50 | = | 0.13 | nM | 9.89 |
| CHEMBL3099249 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3099249 | — | EC50 | = | 1.05 | nM | 8.98 |
| CHEMBL3099248 | — | EC50 | = | 5.02 | nM | 8.30 |
| CHEMBL3099248 | — | EC50 | = | 5.012 | nM | 8.30 |
| CHEMBL3099250 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3099250 | — | EC50 | = | 10.32 | nM | 7.99 |
| CHEMBL3099251 | — | EC50 | = | 12.59 | nM | 7.90 |
| CHEMBL3099251 | — | EC50 | = | 12.59 | nM | 7.90 |
| CHEMBL434 | ISOPROTERENOL | EC50 | = | 31.64 | nM | 7.50 |
| CHEMBL434 | ISOPROTERENOL | EC50 | = | 31.62 | nM | 7.50 |
| CHEMBL434 | ISOPROTERENOL | Activity | - | — | - | |
| CHEMBL3099250 | — | Activity | - | — | - | |
| CHEMBL3099251 | — | Activity | - | — | - | |
| CHEMBL3099248 | — | Activity | - | — | - | |
| CHEMBL3099249 | — | Activity | - | — | - |