Assay Detail

CHEMBL3100994

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Functional

Antineuroinflammatory activity in rat brain neonatal microglia

ChEMBL ↗

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Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗

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NON-PROTEIN TARGET (CHEMBL3879801) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target NON-PROTEIN TARGET

CHEMBL3879801

Anchored from Assay target.

Protein identity NON-PROTEIN TARGET

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Rattus norvegicus
Tissue	Brain
Cell Type	Microglia
Confidence	1 — Organism
Curated By	Autocuration

Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗

Type	NON-MOLECULAR

Publication

Dactyloditerpenol acetate, a new prenylbisabolane-type diterpene from Aplysia dactylomela with significant in vitro anti-neuroinflammatory activity.

Jiménez-Romero C, Mayer AM, Rodríguez AD.
Bioorg Med Chem Lett (2014) 24 : 344 -348
PubMed 24279991 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	7.75	8.49

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL25	ASPIRIN	4.0	1	8.49
CHEMBL563	FLURBIPROFEN	4.0	1	7.00

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL25	ASPIRIN	IC50	=	3.2	nM	8.49
CHEMBL563	FLURBIPROFEN	IC50	=	100.0	nM	7.00