Assay Detail
Binding
CHEMBL3101028
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at P2Y12 receptor in human platelet-rich plasma assessed as inhibition of ADP-induced platelet aggregation incubated for 5 mins prior to ADP-challenge by light transmission-based assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of cyclopentyl-triazolol-pyrimidine (CPTP) based P2Y12 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.83 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3098241 | — | — | 1 | 6.66 |
| CHEMBL3098234 | — | — | 1 | 6.55 |
| CHEMBL3098247 | — | — | 1 | 6.48 |
| CHEMBL3098242 | — | — | 1 | 6.46 |
| CHEMBL398435 | TICAGRELOR | 4.0 | 1 | 6.30 |
| CHEMBL3098243 | — | — | 1 | 5.78 |
| CHEMBL3098240 | — | — | 1 | 5.76 |
| CHEMBL3098246 | — | — | 1 | 5.71 |
| CHEMBL3098250 | — | — | 1 | 5.32 |
| CHEMBL3098244 | — | — | 1 | 5.20 |
| CHEMBL3098239 | — | — | 1 | 4.95 |
| CHEMBL3098238 | — | — | 1 | 4.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3098241 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL3098234 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL3098247 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL3098242 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL398435 | TICAGRELOR | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3098243 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL3098240 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL3098246 | — | IC50 | = | 1970.0 | nM | 5.71 |
| CHEMBL3098250 | — | IC50 | = | 4820.0 | nM | 5.32 |
| CHEMBL3098244 | — | IC50 | = | 6350.0 | nM | 5.20 |
| CHEMBL3098239 | — | IC50 | = | 11280.0 | nM | 4.95 |
| CHEMBL3098238 | — | IC50 | = | 16300.0 | nM | 4.79 |