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Compound Detail

CHEMBL3098239

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CCCSc1nc(N[C@@H]2C[C@H]2c2ccc(F)c(F)c2)c2nnn([C@H]3[C@H](O)[C@H](O)[C@@H](OCCO)[C@@H]3O)c2n1

Basic Information

ChEMBL ID CHEMBL3098239
Phase Preclinical
Structure Type MOL
InChI Key VSUYQYJCUQYWIB-QIIUYWKJSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

538.6
MW (Da)
0.98
ALogP
12
HBA
5
HBD
158.7
PSA (Ų)
0.19
QED
2
Ro5 Violations
10
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H28F2N6O5S
MW 538.58
Aromatic Rings 3
Heavy Atoms 37
NP-Likeness -0.78

Activity Summary

IC50 2 meas. best 5.86

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
P2Y purinoceptor 12
CHEMBL2188
IC50 5.86 5.86 1380.0 1
P2Y purinoceptor 12
CHEMBL2001
IC50 4.95 4.95 11280.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
24332627 10.1016/j.bmcl.2013.11.055 P2Y purinoceptor 12 2

Data from ChEMBL 36 via Core Engine