P2Y purinoceptor 12 · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-13Protein identity stays anchored to UniProt Q9EPX4. Use UniProt Q9EPX4 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9EPX4 as the stable identity anchor, then attach disease evidence before program review.
P2Y purinoceptor 12
Review this target as P2Y purinoceptor 12, mapped to UniProt Q9EPX4. Sequence length is 343 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats P2Y purinoceptor 12 as ChEMBL target CHEMBL2188, mapped to UniProt Q9EPX4. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | P2Y purinoceptor 12 |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | Q9EPX4 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | P2Y purinoceptor 12 |
| UniProt Accession | Q9EPX4 |
| Component Type | Protein |
| Sequence Length | 343 aa |
P2Y purinoceptor 12
Review this target as P2Y purinoceptor 12, mapped to UniProt Q9EPX4. Sequence length is 343 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL336208 | 8.96 | EC50 | 1.1 | Preclinical |
| CHEMBL3325894 | 7.7 | IC50 | 20.0 | Preclinical |
| CHEMBL223344 | 7.6 | EC50 | 25.0 | Preclinical |
| CHEMBL3325891 | 7.22 | IC50 | 60.0 | Preclinical |
| CHEMBL14830 | 7.16 | EC50 | 69.0 | Preclinical |
| CHEMBL335206 | 7.09 | EC50 | 82.0 | Preclinical |
| CHEMBL3098247 | 6.96 | IC50 | 110.0 | Preclinical |
| CHEMBL3098249 | 6.83 | IC50 | 148.0 | Preclinical |
| CHEMBL3325893 | 6.82 | IC50 | 150.0 | Preclinical |
| CHEMBL3098234 | 6.8 | IC50 | 160.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-free format | 3 | 98 | 6.0 |
| cell-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 7 | 6.8 |