Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL3098249

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
CCCSc1nc(N[C@@H]2C[C@H]2c2ccc(F)c(F)c2)c2nnn([C@@H]3C[C@H](OCC(O)CO)[C@@H](O)[C@H]3O)c2n1

Basic Information

ChEMBL ID CHEMBL3098249
Phase Preclinical
Structure Type MOL
InChI Key PDKXOVMOLXKMOG-HRXYOTLZSA-N
1
Targets
1
Activities
1
Assay Types
3
PK Parameters
2
Publications
0
Known Names

Molecular Properties

552.6
MW (Da)
1.37
ALogP
12
HBA
5
HBD
158.7
PSA (Ų)
0.17
QED
2
Ro5 Violations
11
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C24H30F2N6O5S
MW 552.60
Aromatic Rings 3
Heavy Atoms 38
NP-Likeness -0.74

Activity Summary

IC50 1 meas. best 6.83

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
P2Y purinoceptor 12
CHEMBL2188
IC50 6.83 6.83 148.0 1

Pharmacokinetic Data

Parameter Value Units Species
AUC 13.8 ng.hr.mL-1 Rattus norvegicus
Cmax 7.039 nM Rattus norvegicus
T1/2 1.72 hr Rattus norvegicus

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
P2Y purinoceptor 12 IC50 = 148.0 nM 6.83 Antagonist activity at P2Y12 receptor in rat platelet-rich plasma assessed as in... 24332627

Literature References

PubMed DOI Target Context # Activities
24332627 10.1016/j.bmcl.2013.11.055 Rattus norvegicus 5
24332627 10.1016/j.bmcl.2013.11.055 P2Y purinoceptor 12 1

Data from ChEMBL 36 via Core Engine