Assay Detail
Binding
CHEMBL3101038
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Inhibition of rat recombinant CYP11B1 using 11-deoxycortisol as substrate by cell-based assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Cytochrome P450 11B1, mitochondrial (CHEMBL4970) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.10 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3099704 | — | — | 1 | 9.52 |
| CHEMBL3099696 | — | — | 1 | 6.41 |
| CHEMBL3099695 | OSILODROSTAT | 4.0 | 1 | 6.30 |
| CHEMBL287677 | DEXFADROSTAT | 2.0 | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3099704 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL3099696 | — | IC50 | = | 386.0 | nM | 6.41 |
| CHEMBL3099695 | OSILODROSTAT | IC50 | = | 495.0 | nM | 6.30 |
| CHEMBL287677 | DEXFADROSTAT | IC50 | = | 686.0 | nM | 6.16 |