Assay Detail
Binding
CHEMBL3101039
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat recombinant CYP11B2 using 11-deoxycorticosterone as substrate by cell-based assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Cytochrome P450 11B2, mitochondrial (CHEMBL3237) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.63 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3099704 | — | — | 1 | 9.00 |
| CHEMBL3099696 | — | — | 1 | 7.62 |
| CHEMBL3099695 | OSILODROSTAT | 4.0 | 1 | 6.96 |
| CHEMBL287677 | DEXFADROSTAT | 2.0 | 1 | 6.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3099704 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3099696 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3099695 | OSILODROSTAT | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL287677 | DEXFADROSTAT | IC50 | = | 118.0 | nM | 6.93 |