Assay Detail
Binding
CHEMBL3101067
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Inhibition of human CA4 preincubated for 15 mins by stopped-flow CO2 hydration method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Combining the tail and the ring approaches for obtaining potent and isoform-selective carbonic anhydrase inhibitors: solution and X-ray crystallographic studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.04 | 7.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.13 |
| CHEMBL78755 | — | — | 1 | 6.84 |
| CHEMBL3099282 | — | — | 1 | 6.20 |
| CHEMBL3099281 | — | — | 1 | 5.02 |
| CHEMBL21 | SULFANILAMIDE | 4.0 | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL78755 | — | Ki | = | 146.0 | nM | 6.84 |
| CHEMBL3099282 | — | Ki | = | 627.0 | nM | 6.20 |
| CHEMBL3099281 | — | Ki | = | 9540.0 | nM | 5.02 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 9760.0 | nM | 5.01 |