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Assay Detail

CHEMBL3101229

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Streptococcus mutans OMZ65 recombinant sortase A delta-40 mutant using Dabcyl-QALPETGEE-Edans as substrate after 1 hr by fluorescence spectrophotometry
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Streptococcus mutans
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Sortase A inhibitory metabolites from the roots of Pulsatilla koreana.
Lee S, Song IH, Lee JH, Yang WY, Oh KB, Shin J.
Bioorg Med Chem Lett (2014) 24 : 44 -48
PubMed 24360605 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 4.40 4.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL145 CAFFEIC ACID 3.0 1 4.70
CHEMBL3098862 1 4.70
CHEMBL78771 Para-Hydroxymercuribenzoic acid 1 4.46
CHEMBL3098865 1 4.45
CHEMBL3098859 1 4.43
CHEMBL3098861 1 4.38
CHEMBL397730 1 4.22
CHEMBL267963 (+)-PINORESINOL 1 4.17
CHEMBL3098860 1 4.08
CHEMBL3098864 1 -
CHEMBL3098863 1 -
CHEMBL32749 FERULATE -1.0 1 -
CHEMBL425148 MATAIRESINOL 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL145 CAFFEIC ACID IC50 = 20200.0 nM 4.70
CHEMBL3098862 IC50 = 20100.0 nM 4.70
CHEMBL78771 Para-Hydroxymercuribenzoic acid IC50 = 35100.0 nM 4.46
CHEMBL3098865 IC50 = 35900.0 nM 4.45
CHEMBL3098859 IC50 = 37300.0 nM 4.43
CHEMBL3098861 IC50 = 41200.0 nM 4.38
CHEMBL397730 IC50 = 60000.0 nM 4.22
CHEMBL267963 (+)-PINORESINOL IC50 = 67700.0 nM 4.17
CHEMBL3098860 IC50 = 82800.0 nM 4.08
CHEMBL3098864 IC50 > 100000.0 nM -
CHEMBL3098863 IC50 > 100000.0 nM -
CHEMBL32749 FERULATE IC50 > 100000.0 nM -
CHEMBL425148 MATAIRESINOL IC50 > 100000.0 nM -