Assay Detail
Functional
CHEMBL3101425
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human KB-3-1 cells assessed as cell survival after 24 hrs by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB 3-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of novel 2-cyano substituted glycyrrhetinic acid derivatives as inhibitors of cancer cells growth and NO production in LPS-activated J-774 cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.02 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL260926 | — | — | 1 | 6.52 |
| CHEMBL3100034 | — | — | 1 | 5.40 |
| CHEMBL3100035 | — | — | 1 | 5.26 |
| CHEMBL3100029 | — | — | 1 | 5.17 |
| CHEMBL412101 | — | — | 1 | 4.70 |
| CHEMBL3100030 | — | — | 1 | 4.60 |
| CHEMBL3100026 | — | — | 1 | 4.40 |
| CHEMBL3100028 | — | — | 1 | 4.10 |
| CHEMBL3100038 | — | — | 1 | - |
| CHEMBL3100037 | — | — | 1 | - |
| CHEMBL3100036 | — | — | 1 | - |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | - |
| CHEMBL3100027 | — | — | 1 | - |
| CHEMBL1271483 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL260926 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3100034 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3100035 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL3100029 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL412101 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL3100030 | — | IC50 | = | 25200.0 | nM | 4.60 |
| CHEMBL3100026 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL3100028 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL3100038 | — | IC50 | - | — | - | |
| CHEMBL3100037 | — | IC50 | - | — | - | |
| CHEMBL3100036 | — | IC50 | - | — | - | |
| CHEMBL6 | INDOMETHACIN | IC50 | - | — | - | |
| CHEMBL3100027 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1271483 | — | IC50 | > | 100000.0 | nM | - |