Assay Detail
Binding
CHEMBL3101477
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of thrombin (unknown origin) by fluorescence assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Pyridyl Bis(oxy)dibenzimidamide Derivatives as Selective Matriptase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 5.55 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL298415 | — | — | 1 | 6.22 |
| CHEMBL3099583 | — | — | 1 | 5.68 |
| CHEMBL3099587 | — | — | 1 | 5.60 |
| CHEMBL3099586 | — | — | 1 | 5.54 |
| CHEMBL3099814 | — | — | 1 | 5.47 |
| CHEMBL3100168 | — | — | 1 | 5.44 |
| CHEMBL3099589 | — | — | 1 | 5.39 |
| CHEMBL3099588 | — | — | 1 | 5.36 |
| CHEMBL3099812 | — | — | 1 | 5.24 |
| CHEMBL3099585 | — | — | 1 | - |
| CHEMBL3099584 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL298415 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL3099583 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL3099587 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL3099586 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL3099814 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL3100168 | — | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL3099589 | — | Ki | = | 4100.0 | nM | 5.39 |
| CHEMBL3099588 | — | Ki | = | 4400.0 | nM | 5.36 |
| CHEMBL3099812 | — | Ki | = | 5800.0 | nM | 5.24 |
| CHEMBL3099585 | — | Ki | > | 2500.0 | nM | - |
| CHEMBL3099584 | — | Ki | > | 2500.0 | nM | - |