Assay Detail
Functional
CHEMBL3101805
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Cytotoxicity against human BGC823 cells after 48 hrs by MTT assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BGC-823 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, molecular modeling and biological evaluation of N-benzylidene-2-((5-(pyridin-4-yl)-1,3,4-oxadiazol-2-yl)thio)acetohydrazide derivatives as potential anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 4.89 | 5.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3098642 | — | — | 1 | 5.90 |
| CHEMBL3098629 | — | — | 1 | 5.49 |
| CHEMBL3098643 | — | — | 1 | 5.37 |
| CHEMBL3098638 | — | — | 1 | 5.26 |
| CHEMBL3098637 | — | — | 1 | 5.21 |
| CHEMBL3098640 | — | — | 1 | 5.20 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.13 |
| CHEMBL3098651 | — | — | 1 | 5.10 |
| CHEMBL3098641 | — | — | 1 | 5.02 |
| CHEMBL3098639 | — | — | 1 | 5.02 |
| CHEMBL3098631 | — | — | 1 | 4.98 |
| CHEMBL3098633 | — | — | 1 | 4.88 |
| CHEMBL3098634 | — | — | 1 | 4.80 |
| CHEMBL3098647 | — | — | 1 | 4.75 |
| CHEMBL3098652 | — | — | 1 | 4.70 |
| CHEMBL3098648 | — | — | 1 | 4.69 |
| CHEMBL3098646 | — | — | 1 | 4.66 |
| CHEMBL3098645 | — | — | 1 | 4.66 |
| CHEMBL3098635 | — | — | 1 | 4.62 |
| CHEMBL3098649 | — | — | 1 | 4.61 |
| CHEMBL3098136 | — | — | 1 | 4.59 |
| CHEMBL3098630 | — | — | 1 | 4.57 |
| CHEMBL3098632 | — | — | 1 | 4.56 |
| CHEMBL3098650 | — | — | 1 | 4.50 |
| CHEMBL3098644 | — | — | 1 | 4.45 |
| CHEMBL3098636 | — | — | 1 | 4.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3098642 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL3098629 | — | IC50 | = | 3260.0 | nM | 5.49 |
| CHEMBL3098643 | — | IC50 | = | 4320.0 | nM | 5.37 |
| CHEMBL3098638 | — | IC50 | = | 5470.0 | nM | 5.26 |
| CHEMBL3098637 | — | IC50 | = | 6160.0 | nM | 5.21 |
| CHEMBL3098640 | — | IC50 | = | 6340.0 | nM | 5.20 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 7480.0 | nM | 5.13 |
| CHEMBL3098651 | — | IC50 | = | 7940.0 | nM | 5.10 |
| CHEMBL3098641 | — | IC50 | = | 9610.0 | nM | 5.02 |
| CHEMBL3098639 | — | IC50 | = | 9590.0 | nM | 5.02 |
| CHEMBL3098631 | — | IC50 | = | 10580.0 | nM | 4.98 |
| CHEMBL3098633 | — | IC50 | = | 13030.0 | nM | 4.88 |
| CHEMBL3098634 | — | IC50 | = | 15840.0 | nM | 4.80 |
| CHEMBL3098647 | — | IC50 | = | 17840.0 | nM | 4.75 |
| CHEMBL3098652 | — | IC50 | = | 19790.0 | nM | 4.70 |
| CHEMBL3098648 | — | IC50 | = | 20520.0 | nM | 4.69 |
| CHEMBL3098646 | — | IC50 | = | 22050.0 | nM | 4.66 |
| CHEMBL3098645 | — | IC50 | = | 21820.0 | nM | 4.66 |
| CHEMBL3098635 | — | IC50 | = | 24030.0 | nM | 4.62 |
| CHEMBL3098649 | — | IC50 | = | 24510.0 | nM | 4.61 |
| CHEMBL3098136 | — | IC50 | = | 25750.0 | nM | 4.59 |
| CHEMBL3098630 | — | IC50 | = | 26670.0 | nM | 4.57 |
| CHEMBL3098632 | — | IC50 | = | 27540.0 | nM | 4.56 |
| CHEMBL3098650 | — | IC50 | = | 31500.0 | nM | 4.50 |
| CHEMBL3098644 | — | IC50 | = | 35600.0 | nM | 4.45 |
| CHEMBL3098636 | — | IC50 | = | 41630.0 | nM | 4.38 |