Assay Detail
Functional
CHEMBL3102010
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human NPYY4 receptor expressed in HEK293 cells assessed as decrease in isoproterenol-induced cAMP level measured every 30 secs for 360 secs by FLIPR assay
9
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and Synthesis of Peptide YY Analogues with C-terminal Backbone Amide-to-Ester Modifications.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 6.73 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL439904 | — | — | 1 | 6.85 |
| CHEMBL3099723 | — | — | 1 | 6.79 |
| CHEMBL3099722 | — | — | 1 | 6.76 |
| CHEMBL3099724 | — | — | 2 | 6.73 |
| CHEMBL3099721 | — | — | 1 | 6.59 |
| CHEMBL3099727 | — | — | 1 | - |
| CHEMBL3099726 | — | — | 1 | - |
| CHEMBL3099725 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL439904 | — | EC50 | = | 141.0 | nM | 6.85 |
| CHEMBL3099723 | — | EC50 | = | 161.0 | nM | 6.79 |
| CHEMBL3099722 | — | EC50 | = | 173.0 | nM | 6.76 |
| CHEMBL3099724 | — | EC50 | = | 185.0 | nM | 6.73 |
| CHEMBL3099724 | — | EC50 | = | 207.0 | nM | 6.68 |
| CHEMBL3099721 | — | EC50 | = | 254.0 | nM | 6.59 |
| CHEMBL3099727 | — | EC50 | > | 500.0 | nM | - |
| CHEMBL3099726 | — | EC50 | > | 500.0 | nM | - |
| CHEMBL3099725 | — | EC50 | > | 500.0 | nM | - |