Neuropeptide Y receptor type 4 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Neuropeptide Y receptor type 4 shows clinical signal disease relevance led by obesity. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P50391. Start with obesity, then reuse UniProt P50391 as the stable protein anchor across project notes and exports.
Start with obesity, then reuse UniProt P50391 as the stable protein anchor across project notes and exports.
Neuropeptide Y receptor type 4 shows clinical signal disease relevance led by obesity. 1 linked drug remains visible in the same block.
Start review with obesity because it currently carries clinical signal support. Linked drugs include TM30339. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyNeuropeptide Y receptor type 4
Review this target as Neuropeptide Y receptor type 4, mapped to UniProt P50391. Sequence length is 375 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Neuropeptide Y receptor type 4 as ChEMBL target CHEMBL4877, mapped to UniProt P50391. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Neuropeptide Y receptor type 4 is the right protein anchor across sources, using UniProt P50391 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why obesity is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Neuropeptide Y receptor type 4 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P50391 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Neuropeptide Y receptor type 4 |
| UniProt Accession | P50391 |
| Component Type | Protein |
| Sequence Length | 375 aa |
Neuropeptide Y receptor type 4
Review this target as Neuropeptide Y receptor type 4, mapped to UniProt P50391. Sequence length is 375 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Neuropeptide Y receptor type 4 shows clinical signal disease relevance led by obesity.
Start review with obesity because it currently carries clinical signal support. Linked drugs include TM30339. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4276961 | 11.0 | Ki | 0.01 | Preclinical |
| CHEMBL4286615 | 11.0 | Ki | 0.01 | Preclinical |
| CHEMBL5423253 | 11.0 | Ki | 0.01 | Preclinical |
| CHEMBL4873376 | 10.96 | Ki | 0.011 | Preclinical |
| CHEMBL5395013 | 10.92 | Kd | 0.012 | Preclinical |
| CHEMBL4540843 | 10.64 | Ki | 0.023 | Clinical |
| CHEMBL5437701 | 10.61 | Ki | 0.02455 | Preclinical |
| CHEMBL3559801 | 10.52 | EC50 | 0.03 | Preclinical |
| CHEMBL5422869 | 10.52 | Ki | 0.0302 | Preclinical |
| CHEMBL5420881 | 10.51 | EC50 | 0.0307 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 105 | 204 | 7.7 |
| single protein format | 26 | 19 | 8.2 |
| cell membrane format | 3 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 58 | 81 | 7.6 |
| assay format | 7 | 3 | 8.2 |