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Compound Detail

CHEMBL4540843

PANCREATIC POLYPEPTIDE
🧪 Phase II
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🧪 Phase II
CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL4540843
Name PANCREATIC POLYPEPTIDE
Phase Phase II
Structure Type MOL
InChI Key HFDKKNHCYWNNNQ-YOGANYHLSA-N

Known Names

Human pancreatic polypeptide Pancreatic hormone iii Pancreatic polypeptide Pancreatic polypeptide (human) Pancreatic polypeptide human
3
Targets
39
Activities
2
Assay Types
0
PK Parameters
13
Publications
5
Known Names
1
Indications

Molecular Properties

4181.8
MW (Da)

Drug Information

Molecule Type Protein
Chirality Single Enantiomer
USAN Stem -tide

Extended Properties

Molecular Formula C185H287N53O54S2
MW 4181.78

Indications

Diabetes Mellitus, Type 1

Activity Summary

EC50 20 meas. best 9.85
Ki 19 meas. best 10.64

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Neuropeptide Y receptor type 4
CHEMBL4877
 Ki 10.64 9.6113 0.0 15
Neuropeptide Y receptor type 4
CHEMBL4877
 EC50 9.85 8.57 0.1 20
Neuropeptide Y receptor type 5
CHEMBL4561
 Ki 7.77 7.76 17.0 2
Neuropeptide Y receptor type 1
CHEMBL4777
 Ki 6.36 6.355 440.0 2

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Neuropeptide Y receptor type 4 Ki = 0.023 nM 10.64 Binding affinity to human Y4R under hypotonic sodium free condition 37773891
Neuropeptide Y receptor type 4 Ki = 0.03631 nM 10.44 Displacement of [3H]-(9S,12S,15S,19R,E)-4-amino-N-((S)-1-(((S)-1-(((S)-1-amino-3... 37773891
Neuropeptide Y receptor type 4 Ki = 0.037 nM 10.43 Displacement of [3H]-(9S,12S,15S,19R,E)-4-amino-N-((S)-1-(((S)-1-(((S)-1-amino-3... 37773891
Neuropeptide Y receptor type 4 Ki = 0.0955 nM 10.02 Displacement of [3H]UR-KK200 from human Y4R expressed in CHO cells co-expressing... 37773891
Neuropeptide Y receptor type 4 Ki = 0.1 nM 10.0 Displacement of [3H]UR-KK200 from human Y4R expressed in CHO cells co-expressing... 37773891
Neuropeptide Y receptor type 4 EC50 = 0.1413 nM 9.85 Agonist activity at human Y4R expressed in HEK293T cells incubated for 60 mins b... 37773891
Neuropeptide Y receptor type 4 EC50 = 0.15 nM 9.82 Agonist activity at human Y4R expressed in HEK293T cells incubated for 60 mins b... 37773891
Neuropeptide Y receptor type 4 Ki = 0.1622 nM 9.79 Displacement of [3H]-(9S,12S,15S,19R,E)-4-amino-N-((S)-1-(((S)-1-(((S)-1-amino-3... 37773891
Neuropeptide Y receptor type 4 Ki = 0.17 nM 9.77 Displacement of [K4]hPP from human Y4R expressed in CHO cells co-expressing Gqi5... 37773891
Neuropeptide Y receptor type 4 Ki = 0.24 nM 9.62 Displacement of [K4]hPP from human Y4R expressed in CHO cells co-expressing Gqi5... 37773891
Neuropeptide Y receptor type 4 EC50 = 0.2951 nM 9.53 Agonist activity at human neuropeptide Y Y4 receptor expressed in HEK293T cells ... 34748345
Neuropeptide Y receptor type 4 Ki = 0.37 nM 9.43 Displacement of [3H]18 from human NPY Y4 receptor expressed in CHO cells co-expr... 27223253
Neuropeptide Y receptor type 4 Ki = 0.65 nM 9.19 Displacement of [3H](2R,7R)-10 from human NPY Y4 receptor expressed in CHO cells... 27223253
Neuropeptide Y receptor type 4 Ki = 0.68 nM 9.17 Displacement of [3H]UR-KK200 from human Y4 receptor expressed in CHO cells co-ex... 32614182
Neuropeptide Y receptor type 4 Ki = 0.69 nM 9.16 Displacement of [3H]UR-KK200 from human neuropeptide Y Y4 receptor expressed in ... 34748345
Neuropeptide Y receptor type 4 Ki = 0.6918 nM 9.16 Displacement of [3H]UR-KK200 from human neuropeptide Y Y4 receptor expressed in ... 34748345
Neuropeptide Y receptor type 4 Ki = 0.6918 nM 9.16 Displacement of [3H]UR-KK200 from human Y4 receptor expressed in CHO cells co-ex... 32614182
Neuropeptide Y receptor type 4 EC50 = 0.73 nM 9.14 Agonist activity at human NPY Y4 receptor expressed in HEK293 cells co-expressin... 27223253
Neuropeptide Y receptor type 4 EC50 = 1.1 nM 8.96 Agonist activity at human Y4R expressed in HEK293T cells by miniGsi assay 37773891
Neuropeptide Y receptor type 4 EC50 = 1.148 nM 8.94 Agonist activity at human Y4R expressed in HEK293T cells by miniGsi assay 37773891

Literature References

PubMed DOI Target Context # Activities
37773891 10.1021/acs.jmedchem.3c01224 Neuropeptide Y receptor type 4 16
34748345 10.1021/acs.jmedchem.1c01574 Neuropeptide Y receptor type 4 11
32614182 10.1021/acs.jmedchem.0c00426 Neuropeptide Y receptor type 4 8
27223253 10.1021/acs.jmedchem.6b00309 Neuropeptide Y receptor type 4 4
32364733 10.1021/acs.jmedchem.0c00027 Neuropeptide Y receptor type 4 3
32614182 10.1021/acs.jmedchem.0c00426 Unchecked 3
34748345 10.1021/acs.jmedchem.1c01574 Unchecked 3
34748345 10.1021/acs.jmedchem.1c01574 Neuropeptide Y receptor type 1 2
34748345 10.1021/acs.jmedchem.1c01574 Neuropeptide Y receptor type 2 2
34748345 10.1021/acs.jmedchem.1c01574 Neuropeptide Y receptor type 5 2
32614182 10.1021/acs.jmedchem.0c00426 Neuropeptide Y receptor type 1 1
32614182 10.1021/acs.jmedchem.0c00426 Neuropeptide Y receptor type 2 1
32614182 10.1021/acs.jmedchem.0c00426 Neuropeptide Y receptor type 5 1

Data from ChEMBL 36 via Core Engine