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Assay Detail

CHEMBL5372977

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Agonist activity at human Y4R expressed in HEK293T cells incubated for 60 mins by cAMP CAMYEN assay
16
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HEK293T
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Neuropeptide Y receptor type 4 (CHEMBL4877)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

[<sup>3</sup>H]UR-JG102-A Radiolabeled Cyclic Peptide with High Affinity and Excellent Selectivity for the Neuropeptide Y Y<sub>4</sub> Receptor.
Gleixner J, Gattor AO, Humphrys LJ, Brunner T, Keller M.
J Med Chem (2023) 66 : 13788 -13808
PubMed 37773891 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 16 9.83 10.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5437695 2 10.30
CHEMBL5430318 2 10.00
CHEMBL5398948 2 9.90
CHEMBL5423253 2 9.90
CHEMBL4540843 PANCREATIC POLYPEPTIDE 2.0 2 9.85
CHEMBL4873376 2 9.79
CHEMBL5396128 2 9.71
CHEMBL5428340 2 9.40

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5437695 EC50 = 0.05012 nM 10.30
CHEMBL5437695 EC50 = 0.063 nM 10.20
CHEMBL5430318 EC50 = 0.1 nM 10.00
CHEMBL5430318 EC50 = 0.11 nM 9.96
CHEMBL5398948 EC50 = 0.1259 nM 9.90
CHEMBL5423253 EC50 = 0.1259 nM 9.90
CHEMBL5398948 EC50 = 0.13 nM 9.89
CHEMBL4540843 PANCREATIC POLYPEPTIDE EC50 = 0.1413 nM 9.85
CHEMBL4540843 PANCREATIC POLYPEPTIDE EC50 = 0.15 nM 9.82
CHEMBL4873376 EC50 = 0.1622 nM 9.79
CHEMBL5423253 EC50 = 0.17 nM 9.77
CHEMBL4873376 EC50 = 0.17 nM 9.77
CHEMBL5396128 EC50 = 0.195 nM 9.71
CHEMBL5396128 EC50 = 0.2 nM 9.70
CHEMBL5428340 EC50 = 0.3981 nM 9.40
CHEMBL5428340 EC50 = 0.41 nM 9.39