Assay Detail
Binding
CHEMBL5372998
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-(9S,12S,15S,19R,E)-4-amino-N-((S)-1-(((S)-1-(((S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)amino)-5-guanidino-1-oxopentan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-15-(3-guanidinopropyl)-12-(4-hydroxybenzyl)-2,11,14,17,20-pentaoxo-19-(4-(propanamido-2,3-t2)butanamido)-1,3,5,10,13,16,21-heptaazacyclopentacos-3-ene-9-carboxamide from human Y4R expressed in CHO cells coexpressing Gqi5-mtAEQ under isotonic sodium containing buffer condition
9
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
[<sup>3</sup>H]UR-JG102-A Radiolabeled Cyclic Peptide with High Affinity and Excellent Selectivity for the Neuropeptide Y Y<sub>4</sub> Receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 9.16 | 10.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4873376 | — | — | 2 | 10.13 |
| CHEMBL5423253 | — | — | 2 | 10.08 |
| CHEMBL4540843 | PANCREATIC POLYPEPTIDE | 2.0 | 1 | 9.79 |
| CHEMBL5428989 | — | — | 2 | 8.18 |
| CHEMBL5411178 | — | — | 2 | 7.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4873376 | — | Ki | = | 0.07413 | nM | 10.13 |
| CHEMBL4873376 | — | Ki | = | 0.076 | nM | 10.12 |
| CHEMBL5423253 | — | Ki | = | 0.08318 | nM | 10.08 |
| CHEMBL5423253 | — | Ki | = | 0.088 | nM | 10.06 |
| CHEMBL4540843 | PANCREATIC POLYPEPTIDE | Ki | = | 0.1622 | nM | 9.79 |
| CHEMBL5428989 | — | Ki | = | 6.607 | nM | 8.18 |
| CHEMBL5428989 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL5411178 | — | Ki | = | 10.23 | nM | 7.99 |
| CHEMBL5411178 | — | Ki | = | 11.0 | nM | 7.96 |