Assay Detail
Functional
CHEMBL4841982
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human neuropeptide Y Y4 receptor expressed in HEK293T cells co-expressing CRE-controlled gene reporter firefly luciferase assessed as relative luminescence measured after 15 mins
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
N-Terminus to Arginine Side-Chain Cyclization of Linear Peptidic Neuropeptide Y Y<sub>4</sub> Receptor Ligands Results in Picomolar Binding Constants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 8.52 | 9.53 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4540843 | PANCREATIC POLYPEPTIDE | 2.0 | 1 | 9.53 |
| CHEMBL4856311 | — | — | 1 | 8.85 |
| CHEMBL4870168 | — | — | 1 | 7.92 |
| CHEMBL4865048 | — | — | 1 | 7.77 |
| CHEMBL4873376 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4540843 | PANCREATIC POLYPEPTIDE | EC50 | = | 0.2951 | nM | 9.53 |
| CHEMBL4856311 | — | EC50 | = | 1.413 | nM | 8.85 |
| CHEMBL4870168 | — | EC50 | = | 12.02 | nM | 7.92 |
| CHEMBL4865048 | — | EC50 | = | 16.98 | nM | 7.77 |
| CHEMBL4873376 | — | EC50 | = | 588843655.36 | nM | - |