Assay Detail
Binding
CHEMBL3102253
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human butyrylcholine esterase
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Multifunctional cholinesterase and amyloid Beta fibrillization modulators. Synthesis and biological investigation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.35 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3099496 | — | — | 1 | 10.22 |
| CHEMBL489454 | — | — | 1 | 9.09 |
| CHEMBL129108 | — | — | 1 | 8.78 |
| CHEMBL3099497 | — | — | 1 | 8.08 |
| CHEMBL3099500 | — | — | 1 | 7.67 |
| CHEMBL3099498 | — | — | 1 | 7.39 |
| CHEMBL3099499 | — | — | 1 | 7.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3099496 | — | Ki | = | 0.06 | nM | 10.22 |
| CHEMBL489454 | — | Ki | = | 0.82 | nM | 9.09 |
| CHEMBL129108 | — | Ki | = | 1.65 | nM | 8.78 |
| CHEMBL3099497 | — | Ki | = | 8.26 | nM | 8.08 |
| CHEMBL3099500 | — | Ki | = | 21.26 | nM | 7.67 |
| CHEMBL3099498 | — | Ki | = | 40.9 | nM | 7.39 |
| CHEMBL3099499 | — | Ki | = | 61.77 | nM | 7.21 |